(L-450) Nucleophilic aromatic substitution on Pyridine: Resonance, Mechanism and Selectivity. Video
#Nucleophilicaromaticsubstitution, #AromaticNucleophilicSubstitution, #NucleophilicSubstitution, #pyridine, #heterocyclicchemistry,
In this lecture, I have discussed the Nucleophilic aromatic substitution on Pyridine nucleus which is electron deficient, six-member heterocyclic compound. Due to its electron deficiency pyridine is activated towards the aromatic nucleophilic substitution (ANS) and rate of reaction is enhanced on the otho and para-position due to the relatively higher extent of positive charge or electron deficiency. I have provided the mechanism of the reaction as must as possible.
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